SDMD (Sarcoglycan Deficient Muscular Dystrophy)
SDMD is a form of limb-girdle muscular dystrophy associated with a mutation in a muscle sarcoglycan gene has been identified in young miniature Dachshunds from Australia, South Africa, and the US. Clinical signs, first noted at approximately 6 months of age were variable and included exercise intolerance, stiff gait, myoglobinuria and dysphagia. The serum CK activity was markedly and persistently elevated. Histopathology of muscle biopsies showed a dystrophic phenotype and immunofluorescent stainings showed all sarcoglycan proteins were markedly decreased or absent.
A DNA test is available from the University of Minnesota in the United States.
For full details of how to have this test done at the University of Minnesota,
Please click here:- SDMD DNA Test instructions
A SDMD DNA test is also available from Orivet Australia.
Full details are available on Orivet’s website.